I understand that you have an input .csv file containing Uniprot IDs and you need to calculate the average percentage of specific amino acid residues in the proteins associated with each organism mentioned in column A.
To accomplish this, we can follow these steps:
Read the input .csv file: We'll start by parsing the .csv file to extract the necessary information, specifically the Uniprot IDs and the corresponding organisms.
Retrieve protein sequences: Using the Uniprot IDs, we'll fetch the protein sequences for each organism from the Uniprot database or any relevant protein database.
Merge protein sequences: Once we have the protein sequences for each organism, we'll merge them into a single long sequence for each organism.
Calculate the average percentage: Next, we'll count the occurrences of the specified amino acid residues (I, V, Y, W, R, E, and L) in each merged sequence. We'll then divide the total count of these residues by the total number of all letters in the sequence to obtain the average percentage.
Generate results: Finally, we'll store the calculated average percentages for each organism, which can be outputted in a suitable format such as a new .csv file or any other desired format.
If you have any specific requirements regarding the programming language or any additional considerations, please let me know. I'm here to assist you further and answer any questions you may have.
Best regards,